Nontoxic Plant Compounds Show Promise Against Hepatitis C Infection

Nontoxic Plant Compounds Show Promise Against Hepatitis C Infection

Click on Image for Hepatitis C Infographic

Approximately 270-300 million people worldwide are infected with hepatitis C, and about 1%-2% of the U.S. population is infected.

This infectious disease can lead to scarring of the liver, cirrhosis, and eventually liver failure. A significant number of infected patients develop liver disease or cancer. The current standard treatment is interferon, which has only a 50% success rate. Compounding the 50% failure rate are severe side effects which lead many people to discontinue treatment.

Researcher Dr. Samuel Wheeler French Jr is a liver pathologist who is currently developing a proteomic-based program to study the development of liver cancer from hepatitis C viral infection. His most recent study results evaluate the effects of several flavonoids on hepatitis C viral infection. Previously, Dr. French has shown that quercetin, a plant-derived bioflavonoid used by some as a nutritional supplement, attenuates Hepatitis C virus production with no cell toxicity.

In his most recent research, French and colleagues found that two other bioflavonoids, catechin and naringenin, displayed antiviral activity on tissue culture. The next step is to determine through a Phase I Clinical Trial that they are safe for patients with chronic hepatitis C infection.

“We now have several new compounds we can test to see if they reduce virus infection,” said Dr. French. “The positive thing about this family of compounds is that they are nontoxic, and can be taken at high doses. Bioflavonoids represent a very promising therapy with very few side effects that could help millions of people.”

Reference for: Nontoxic Plant Compounds Show Promise Against Hepatitis C Infection

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