A study has found that type 2 diabetes patients receiving self-donated bone marrow stem cell transplants required less insulin after the transplants, when compared to a control group of type 2 diabetes patients who did not receive transplants.
“There is growing interest in the scientific community for cellular therapies that use bone marrow-derived cells for the treatment of type 2 diabetes mellitus and its complications,” said study corresponding author Anil Bhansali. “But the potential of stem cell therapy for this disease is yet to be fully explored.”
While there is growing interest in using stem cell transplantation to treat type 2 diabetes, few studies have examined the utility of bone marrow-derived stem cells. By experimenting with bone marrow-derived stem cells, the researchers sought to exploit the rich source of stem cells in bone marrow.
Their study aimed at evaluating the efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes and who also had good glycemic control. Good glycemic control emerged as an important factor in the transplantation group and in the non-transplanted control group.
Cell transplantation had a significant impact on the patients in this study as those administered cells demonstrated a significant reduction in insulin requirement. A significantly smaller reduction in the insulin requirement of the control group was also observed but a “repeated emphasis on life style modification” was believed to be a contributing factor in this effect.
According to Dr. Bhansali, the strength of their study included the inclusion of a homogenous patient population with type 2 diabetes which exhibited good glycemic control, and the presence of a similar control group that did not get cell transplants.
“The efficacy and safety of stem cell therapy needs to be established in a greater number of patients and with a longer duration follow-up,” concluded Bhansali and his co-authors. “The data available so far from animal and human studies is encouraging, however, it has enormous limitations.”
The researchers recommended determining which type of stem cells -hematopoietic, bone marrow or placenta-derived – might be best to treat type 2 diabetes. In addition, they said that post-transplantation patients needed close monitoring for the development of neoplasia as stem cells – whether multipotent or pluripotent – have the potential for malignant transformation.
They concluded that “autologous bone marrow-derived stem cell therapy in patients with type 2 diabetes results in significant decrease in insulin dose requirement.”